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Summary Lutein and zeaxanthin are overall safe to supplement at the recommended doses, but more research is required to assess the potential health effects

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To confirm the temperature-dependent stability of the GSH-OPA adduct, the assay was performed at 4 C, 25 C and 50 C (Figure 3B)

Following crossover to HA + GSH-C4 (V3 to V6), directional increases were observed for several mediators, although these changes did not achieve statistical significance compared to baseline, mirroring the trends seen in clinical outcomes for this sequence